From Click Chemistry to Fluorescent Molecular Logic Gates

Authors: David Magri

Corresponding: David Magri (

Keywords: Click chemistry, Triazole, Photoinduced electron transfer, Fluorescence, Molecular logic gates, Pourbaix sensor

Doi: 10.7423/XJENZA.2023.1.10

Issue: Xjenza Online Vol. 11 Special Issue (Top Scientists)

The 2022 Nobel Prize in Chemistry was awarded for the inventions of click chemistry and biorthogonal chemistry, which culminated from trans-disciplinary research in the areas of organic synthesis, fluorescence imaging and chemical biology. In this mini-review, the inventions of the Pourbaix sensor and the Lab-on-a-Molecule, both examples of purposely designed and synthesised functional molecules with fluorescence properties, are discussed. These intelligent molecules operate on the premise of a competitive tension between non-radiative photoinduced electron transfer (PET), and radiative fluorescence. Redox, acid-base and ion-binding equilibrium modulate the states of these molecular devices. Potential applications of these inventions in corrosion detection, cell imaging and health diagnostics for the benefit of society are presented.

Download Article: