Cannabinoids For Fibromyalgia: An Updated Systematic Review

Authors: Jean Claude Scicluna, Giuseppe Di Giovanni

Corresponding: Giuseppe Di Giovanni (

Keywords: fibromyalgia, chronic pain, cannabis, cannabinoids, pharmacotherapy

Doi: 10.7423/XJENZA.2023.1.05

Fibromyalgia is an increasingly prevalent condition resulting in high morbidity and economic burden for sufferers. Minimal to modest benefit has been achieved by pharmacotherapies, creating a strong rationale for novel therapies. Substantial evidence has implicated the endocannabinoid system in the modulation of fibromyalgia symptoms. However, the therapeutic potential and potential adverse effects of cannabis-based therapy in fibromyalgia are still under-reported, leading to clinicians’ hesitation to opt for such therapy. This systematic review examined the literature and provided a critical review of the safety and efficacy of cannabis-based therapy in fibromyalgia. It resulted that medical cannabis is a safe and effective treatment option for fibromyalgia, whilst further research in this area is needed.

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